333 North Main Street, Richfield, UT 84701, Utah, United StatesShow on map. Both business travelers and tourists can enjoy the propertys. Sylo Hotel Richfield, a Ramada by Wyndham. Ouachita Hotel and adjoining buildings in business section damaged. This property affirms that it follows the cleaning and disinfection practices of Count on Us (Wyndham). Stop at SYLO Hotel Richfield, a Ramada by Wyndham to discover the wonders of Richfield (UT). Origin of blaze undetermined 10 SALINA, UTAH Cafe, rooming house and residence. Sylo Hotel Richfield, < 0.1 mile NNW, 3.0, 0 - 0. Realtime driving directions to Sylo Hotel by Boutique Collections, Richfield, 333 N Main St, Richfield, based on live. Right in the center of Richfield by the Main Street/US 89 junction, the Ramada is within walking distance of many. Richfield City Police Department nearby hotel search is centered on latitude 38.7683 & longitude. Masks are required in public areas for unvaccinated guests. SYLO Hotel Richfield, a Ramada by Wyndham. Disinfectant is used to clean the property commonly-touched surfaces are cleaned with disinfectant between stays bed sheets and towels are laundered at a temperature of at least 60☌/140☏ guestroom doors are sealed after cleaning. This property advises that enhanced cleaning and guest safety measures are currently in place. Ramada by Wyndham Richfield UT provides amenities like free continental breakfast and a 24-hour business center. Cash is not accepted. For guests' safety, the property includes a fire extinguisher and a smoke detector in each accommodation. This property accepts Visa, Mastercard, American Express, Discover, Diners Club, and JCB International. The provision of housing is linked to their trade, business, or profession. This property is managed by a professional host. Special requests can't be guaranteed and may incur additional charges. Special requests are subject to availability at the time of check-in. Safety features at this property include a fire extinguisher and a smoke detectorīe prepared: check the latest COVID-19 travel requirements and measures in place for this destination before you travel.Ĭharges for extra guests may apply and vary according to property policy.Ī cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in. This property accepts credit cards cash is not accepted Phone number, Photo, Opening hour, Payment method and Map details of. Buy the Gift Card accepted at Sylo Hotel - Richfield and any other independent business in Richfield, UT. Special requests are subject to availability upon check-in and may incur additional charges special requests cannot be guaranteed Best Western Richfield Inn is a Hotel located in 1275 N Main St, Richfield, Utah, US. Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges Located just outside of Richfield, Utah, Annabella Land & Cattles. Traveling on business Take advantage of the. Homes Details: Lowest Price Most Recent More colors Nuclear Missile Silo Patent Print. Free self parking is available onsite.Extra-person charges may apply and vary depending on property policy This hotel doesnt skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Conveniences include desks and coffee/tea makers, and housekeeping is provided on request.Featured amenities include a 24-hour business center, a 24-hour front desk, and a safe deposit box at the front desk. From 29/night - Compare 32 cheap motels from Booking,, Vrbo, Airbnb etc in. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. At SYLO Hotel Richfield, a Ramada by Wyndham, our welcoming atmosphere and convenient amenities, such as free WiFi, offer an ideal stay in Richfield, UT. The Sylo was formerly a Days Inn, and by the look of things. Complimentary wireless Internet access keeps you connected, and digital programming is available for your entertainment. Latest reviews, photos and ratings for Days Inn by Wyndham Richfield at 333 N Main St. This family-friendly hotel is 1.3 mi (2 km) from Snow College Richfield Campus and 28.8 mi (46.3 km) from Fremont Indian State Park.A complimentary continental breakfast is served daily from 7:00 AM to 10:00 AM.Make yourself at home in one of the 51 air-conditioned rooms featuring refrigerators and microwaves. Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless Internet access and concierge services.A stay at Ramada by Wyndham Richfield UT places you in the heart of Richfield, steps from Fishlake National Forest and a 2-minute drive from Sevier Valley Center.
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These results suggest that the DXd-ADC technology is widely applicable to various target antigens for cancer therapy. In the preclinical setting, the DXd-ADC technology has been effective when applied to target other cancer-associated antigens as well ( 10–12). These features enable the wide therapeutic window of the ADC with high antitumor potency and less systemic toxicity ( 9). The DXd-ADC technology has desirable characteristics for ADC including a highly potent payload (DXd) with a short systemic half-life, a cleavable linker designed to be tumor selective which is stable in circulation, and an average drug-to-antibody ratio (DAR) up to 8 being optimized for each target. Trastuzumab deruxtecan has received an accelerated approval from FDA and PMDA for patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. Trastuzumab deruxtecan (ENHERTU, T-DXd, DS-8201), a novel HER2-directed ADC with this DXd-ADC technology, demonstrated potent antitumor activity with acceptable safety profiles in preclinical models and patients with HER2-positive cancers ( 2, 4–8). Recently, we developed a novel ADC technology platform with a novel DNA topoisomerase I (Topo I) inhibitor, DXd, and a cleavable tetrapeptide-based linker ( 2, 3). These results suggest Dato-DXd could be a valuable treatment option for patients with TROP2-expressing tumors in the clinical setting. Safety profiles of Dato-DXd in rats and cynomolgus monkeys were acceptable.ĭato-DXd demonstrated potent antitumor activity against TROP2-expressing tumors by efficient payload delivery into tumors and acceptable safety profiles in preclinical models. Dato-DXd also showed potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC PDX models. Dato-DXd exhibited in vivo antitumor activity with DNA damage induced by the accumulated DXd in TROP2-expressing xenograft tumors, but neither isotype control IgG-ADC nor anti-TROP2 antibody had this effect. Safety profiles were also assessed in rats and cynomolgus monkeys.ĭato-DXd bound specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and DXd release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro. The pharmacologic activity and mechanism of action of Dato-DXd were investigated in several human cancer cell lines and xenograft mouse models including patient-derived xenograft (PDX) models. We developed the novel TROP2-directed antibody–drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a), with a potent DNA topoisomerase I inhibitor (DXd), and evaluated its antitumor activity and safety profiles in preclinical models. Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. 229Thorium-doped calcium fluoride for nuclear laser spectroscopy. Computer modelling of thorium doping in LiCaAlF 6 and LiSrAlF 6: application to the development of solid state optical frequency devices. Attempt to optically excite the nuclear isomer in 229Th. Results of a direct search using synchrotron radiation for the low-energy 229Th nuclear isomeric transition. Multiply charged thorium crystals for nuclear laser spectroscopy. Laser ablation loading of a radiofrequency ion trap. Charge and energy distributions of recoils from Th 226 alpha decay. Development of a recoil ion source providing slow Th ions including 229(m)Th in a broad charge state distribution. Determination of the extraction efficiency for 233U source α-recoil ions from the MLL buffer-gas stopping cell. Atomic susceptibilities and shielding factors. Two-photon laser excitation of trapped 232Th + ions via the 402-nm resonance line. Trapping and sympathetic cooling of single thorium ions for spectroscopy. Electronic level structure of Th + in the range of the 229mTh isomer energy. Wigner crystals of 229Th for optical excitation of the nuclear isomer. Nuclear radii of thorium isotopes from laser spectroscopy of stored ions. 27Al + quantum-logic clock with a systematic uncertainty below 10 −18. Optical clock comparison for Lorentz symmetry testing. Electromagnetic traps for charged and neutral particles. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion. Alternative approach to populate and study the 229Th nuclear clock isomer. Precise γ-spectroscopy measurement of the isomer energy. Energy splitting of the ground-state doublet in the nucleus 229Th. On the energy of the 3.5-eV level in 229Th. Lifetime measurement of the 229Th nuclear isomer. Reduced transition probabilities for the gamma decay of the 7.8 eV isomer in 229Th. Magnetic dipole and electric quadrupole moments of the 229Th nucleus. Laser spectroscopic investigation of properties of the 229 Th isomer. Laser spectroscopic characterization of the nuclear-clock isomer 229mTh. Nuclear structure of lowest 229Th states and time-dependent fundamental constants. Litvinova, E., Feldmeier, H., Dobaczewski, J. Hyperfine structure of the atomic spectrum and the nuclear moments of the thorium-229 isotope. Uses for uranium-233: what should be kept for future needs? ORNL 6952, 7 (1999). The 229Th isomer: prospects for a nuclear optical clock. 7th Symposium on Frequency Standards and Metrology, ISFSM 2008, 532–538 (World Scientific, 2009). Prospects for a nuclear optical frequency standard based on thorium-229. Properties of the optical transition in the 229Th nucleus. Lasers as a bridge between atomic and nuclear physics. The 229-thorium isomer: doorway to the road from the atomic clock to the nuclear clock. Nuclear clocks based on resonant excitation of γ-transitions. Features of the low-energy level scheme of 229Th as observed in the α-decay of 233U. A detailed theoretical analyis of the achievable accuracy of a 229 Th nuclear clock with trapped ions. Single-ion nuclear clock for metrology at the 19th decimal place. Proposal of a high-precision optical nuclear clock based on 229 Th.Ĭampbell, C. Nuclear laser spectroscopy of the 3.5 eV transition in Th-229. A new method of measuring nuclear magnetic moment. Über die hyperfeinstruktur des Europiums. Zur Frage der theoretischen Deutung der Satelliten einiger Spektrallinien und ihrer Beeinflussung durch magnetische Felder. Because the nuclear transition energy is in the range of transitions of valence electrons, the electronic state may influence the nuclear excitation and decay rates.īecause of a fine balance of contributions from the strong and electromagnetic interactions to the nuclear transition energy, a 229Th clock would be sensitive to predicted effects of physics beyond the standard model, such as temporal or spatial variations of fundamental constants. Thorium-229 is studied as trapped atomic ions in vacuum or doped into transparent crystals such as CaF 2. Recent experiments have provided essential information on the nuclear properties of 229Th (half-life 7,920 years), such as the nuclear moments, decay modes of the isomer and a more precise value of the isomer excitation energy, which is required to achieve laser excitation. The 229Th nucleus is the prime candidate for the realization of a nuclear clock because it possesses a low-energy (8 eV) excited state that is amenable to resonant laser excitation from the nuclear ground state, with an expected natural linewidth in the millihertz range. A nuclear clock, based on a radiative transition in the nucleus, is less sensitive to external perturbations and therefore potentially more precise than established atomic clocks that are based on transitions in the electron shell. A single space was added to the front and a single mark to the end to act as start and stop bits. Data was recorded in eight-bit bytes, least significant bit first, with a parity bit added to seven-bit data if needed. This produces an overall data rate of 300 Hz. KCS was a simple FSK system that recorded zeros as four cycles of a 1200 Hz tone and ones as eight cycles of 2400 Hz. It was created by a group of S-100 bus manufacturers at a meeting hosted by Byte Magazine in November 1975 in Kansas City. The Kansas City Standard (KCS) was one of the few cassette formats that was standardized to any degree. Īssembler code programs for reading and writing on Intel 8080 machines were provided. This meant every bit in the recording was self-timed, allowing it to easily survive tape stretch and other problems that changed the frequency or playback speed. If the on portion of the pulse was shorter than the off period, it was a 0 if the on portion was longer than off, it was 1. This was compared to the time between the on-to-off and the next off-to-on marking the start of the next bit. The pulse lengths were measured by recording the time between the off-to-on transition when the carrier turned on and the on-to-off transition when it dropped again. Zeros were recorded as short pulses, and ones long, with the overall bit time being a nominal 2.5 milliseconds when used at 2 kHz. This means that a 10 kHz carrier allows about 2,500 bps speeds. The article goes on to note that the basic concept works well at any frequency and that the system is capable of recording at data at a rate of about 1⁄ 4 of the carrier. Any suitable carrier frequency could be used, with 2000 Hz being suggested. In contrast to almost every other system of the era, HITS did not use FSK for its storage mechanism instead it used pulse-width modulation, or PWM. The Hobbyist Interchange Tape System (HITS) was introduced by Jerry Ogdin in a September 1975 article in Popular Electronics magazine. There was no support for reading and writing the data in the basic operating system users had to type in their own loader program to do so, although the hexadecimal example version of the code was provided and is quite small. Files were prefixed with four seconds of space signals to provide clock recovery, and then all of the data written in a single stream. Bytes were written with a single mark bit, eight data bits, and a final odd parity bit. This used a frequency-shift keying (FSK) system, with binary zeros ("space") represented by one cycle of a 2 kHz signal, and ones ("mark") as a cycle of 0.8 kHz. As part of this process, a cassette interface was developed. I sat many hours with a pen, laboriously copying all the songs and track numbers on to a cassette insert so I'd remember which tape was which.One of the earliest efforts to develop a microcomputer for home use was carried out in the early 1970s at RCA and led to the COSMAC processor design. Where do you think the term "mix tape" came from? It was from those of us who would put together our favorite music all on one tape, generally for road trip purposes. I think every 80s teen probably has a collection of homemade tapes. There's no telling how much money I spent on blank cassettes to either record friends' tapes (on a double deck cassette), or to record songs from the radio. We were ingenious little rascals when it came to our music! Or winding the tape back taut inside the cassette with the barrel of a pen. You'd usually get a couple of seconds of drop out, but it was surprisingly little. So frustrating! You had to cut the tape so it would be even and then Scotch tape the ends together. I also remember when the tape would break. It was just about enough for most of an album on each side. That meant 45 minutes of music on each side. Remember recording most of one side of a tape and looking carefully at the remaining tape to see if we could squeeze just one more song on it before the tape ran out? It was a great day when 90-minute cassettes were released. You forge alliances and together you take on your enemies. You do your best to keep your population happy. 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A December 2021 review of 16 studies evaluating SCS for chronic pain relief found the incidence of infection in SCS implantation ranged from 3 to 7 percent, while it ranged from 2 to 31 percent in reoperation/reimplantation procedures. Efficacy decreases over time (by about three years) for about 30 percent of patients, as shown in multiple retrospective studies of patients with failed back surgery syndrome and in a randomized, controlled trial in complex regional pain syndrome (CRPS) patients. This device has limited effectiveness, usually with only 50 to 70 percent pain relief. The original type of SCS device is called tonic stimulation (traditional low frequency). Spinal cord stimulators (SCS) are usually an end-stage treatment for chronic neuropathic pain. Socioeconomic Impact of Natural Resources Projects.Violation of Non-Competition Agreements.
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